Cancer Genetics and Risk Management Clinic

Some people inherit a genetic predisposition for developing cancer. It is very important that these high-risk patients receive counseling to understand the genetic mutation, plus preventive monitoring and extra screenings to ensure early detection, should a cancer diagnosis occur. If genetic testing or family history indicate that you are at an elevated risk for developing cancer, CARTI’s Cancer Genetic and Risk Management Clinic can help you get in front of it. Our team of multidisciplinary genetic specialists provides patients with genetic testing, counseling, monitoring and screenings.

What to Expect

Now Accepting Patients
No physician referral needed.

Monday – Thursday, 8 a.m. to 5 p.m.
Friday, 8 a.m. to 1 p.m.

8901 CARTI Way Little Rock



Click here to learn more about CARTI’s wide range of cancer treatment services.

Understanding Genetic Counseling

In the most basic terms, cancer is caused by changes to genes that control the way cells grow and divide. Some of these cancer-causing genetic changes are acquired during a person’s lifetime, but others are inherited from parents. This is where cancer genetics comes in – studying hereditary and familial cancer.

Marianne Lotito, MS, CGC, is leading CARTI’s genetic counseling program. She has 20 years of experience in genetic counseling, including program implementation of genetic testing for hospitals and oncology practices around the country, as well as direct patient care.

With genetic counseling, she and our cancer genetics team can help people understand and adapt to the medical, psychological and familial implications of genetic risk for disease. The process includes:

While only about 10 percent of cancers are hereditary, our team goal at CARTI is to reduce the mortality rate of cancer in Arkansas, which is higher than the national average. Genetic counselors occupy a small but important slice of this fight by helping to identify individuals at risk for hereditary breast and ovarian cancer, hereditary colon cancer and other inherited forms of cancer.

After a cancer diagnosis, genetic testing can help answer the question, “Why me?” Moving forward, it can help inform how treatment should proceed – including radiation, surgery and chemotherapy. After looking at the results of genetic testing, we can also help other family members understand the benefits of testing so that we can promote awareness, early detection and prevention for even more people.

Who should see a cancer genetic counselor?

In some families a pattern of cancer is obvious. In others, it may be difficult to detect a pattern due to small family size, incomplete family histories or inability to document diagnoses. Patients with the following should consider cancer genetic counseling:

Other patients who may benefit include: 

Genetic Spotlight: BRCA1 and BRCA2

Because of high-profile figures such as Angelina Jolie, most people are familiar with the BRCA1 and BRCA2 genes. Individuals with a mutation in one of these genes have a 55 to 87 percent risk of breast cancer and an increased risk – 64 percent – of a second new occurrence of breast cancer.
Patients with this mutation are also at increased risk of ovarian, pancreatic and prostate cancers. In fact, the risk for ovarian cancer is 63 percent, in comparison to 1 in 71 for all women.

If this gene mutation is detected, the recommendation is to consider increased surveillance. Starting a routine of breast surveillance with mammogram and breast MRI alternating every six months is recommended for women at greatly elevated risk.

Women with a gene mutation may also be advised to take the birth control pill to reduce the risk of ovarian cancer, or tamoxifen, which can reduce the risk of breast cancer. Preventive surgery is another possible option. Women at high risk for ovarian cancer may have their ovaries removed after childbearing is complete.

Genetic Spotlight: Lynch Syndrome

Lynch syndrome – also known as hereditary nonpolyposis colorectal cancer – is a common inherited disorder that increases the risk of many types of cancer, especially cancers of the colon and uterus. For most people, guidelines call for the first colonoscopy at age 50. However, if we know a person has a mutation in one of the Lynch genes, the recommendation would be to start colonoscopy at a younger age (40 years old) and screen annually. This helps prevent cancer or detect it earlier, which ultimately helps lower the mortality rate.

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